Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration
نویسندگان
چکیده
منابع مشابه
Motor axon excitability during Wallerian degeneration.
Axonal loss and degeneration are major factors in determining long-term outcome in patients with peripheral nerve disorders or injury. Following loss of axonal continuity, the isolated nerve stump distal to the lesion undergoes Wallerian degeneration in several phases. In the initial 'latent' phase, action potential propagation and structural integrity of the distal segment are maintained. The ...
متن کاملTransient, Focal Accumulation of Axonal Mitochondria during the Early Stages of Wallerian Degeneration
Wallerian degeneration was produced in guinea pig sciatic nerves by a crush injury. At intervals of 2, 12, 24, 36, 48, 72, and 96 hours after the crush, the nerves were fixed in osmium tetroxide, and blocks from the distal, degenerating segment identified topographically prior to embedding in Araldite or Epon. Phase and electron microscopic study of serial cross- and longitudinal sections revea...
متن کاملComplement depletion reduces macrophage infiltration and activation during Wallerian degeneration and axonal regeneration.
After peripheral nerve injury, macrophages infiltrate the degenerating nerve and participate in the removal of myelin and axonal debris, in Schwann cell proliferation, and in axonal regeneration. In vitro studies have demonstrated the role serum complement plays in both macrophage invasion and activation during Wallerian degeneration of peripheral nerve. To determine its role in vivo, we deplet...
متن کاملThe slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids are terminal endbulbs of axon stumps, but swellings may also occur on unbroken axons and their role in axon loss re...
متن کاملThe slow Wallerian degeneration gene, Wld, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
Correspondence: Dr Michael Coleman, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK E-mail: [email protected] *W. Mi and B. Beirowski contributed equally to this work ZMMK and Institute for Genetics and Department of Anatomy I, University of Cologne, Cologne, Germany, Division of Neuroscience, University of Edinburgh, Edinburgh, The Babraham Institute, Babraham, Cambridge, UK,...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2013
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2013.03.009